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Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp.
Longeon, Arlette; Copp, Brent R; Quévrain, Elodie; Roué, Mélanie; Kientz, Betty; Cresteil, Thierry; Petek, Sylvain; Debitus, Cécile; Bourguet-Kondracki, Marie-Lise.
Afiliación
  • Longeon A; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
  • Copp BR; Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
  • Quévrain E; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
  • Roué M; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
  • Kientz B; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
  • Cresteil T; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Centre de Recherche de Gif, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France.
  • Petek S; Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France.
  • Debitus C; Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France.
  • Bourguet-Kondracki ML; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
Mar Drugs ; 9(5): 879-888, 2011.
Article en En | MEDLINE | ID: mdl-21673896
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A2 (PLA2), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Indoles Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Indoles Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza