Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects.
Br J Clin Pharmacol
; 72(6): 985-9, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21671987
AIM: To see if adult age correlates with ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. METHODS: Sixty healthy drug free subjects were recruited in the age groups 18-39, 40-64 and ≥65 years. Plasma albumin concentrations were determined. Ex vivo unbound fractions (f(u)) were assessed by spiking samples and measuring the free and total concentrations. RESULTS: No correlation of age with f(u) was seen. The study was powered to demonstrate a change in f(u) of ≥7-10%. A decline in plasma albumin concentration of ~0.03 g l(-1) year(-1) was seen with increasing age (P= 0.032) and was associated with increased f(u) of lorazepam (P= 0.009) and oxazepam (P= 0.014). CONCLUSIONS: There was no association of adult age with ex vivo f(u) of lorazepam, oxazepam or temazepam in healthy subjects.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazepam
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Temazepam
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Albúmina Sérica
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Lorazepam
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda
Pais de publicación:
Reino Unido