Copper-catalyzed direct thiolation of azoles with aliphatic thiols.

Zhou, An-Xi; Liu, Xue-Yuan; Yang, Ke; Zhao, Shu-Chun; Liang, Yong-Min

Zhou, An-Xi; Liu, Xue-Yuan; Yang, Ke; Zhao, Shu-Chun; Liang, Yong-Min.

Afiliación

Zhou AX; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.

Org Biomol Chem ; 9(15): 5456-62, 2011 Aug 07.

Article en En | MEDLINE | ID: mdl-21647519

RESUMEN

Cu(II)-catalyzed direct thiolation of azoles with thiols is described via intermolecular C-S bond formation/C-H functionalization under oxidative conditions. Both aryl thiols and aliphatic thiols are used as coupling partners, and furnished the thiolation products in moderate to good yields. The reaction is compatible with a wide range of heterocycles including oxazole, thiazole, imidazole and oxadiazole.

Asunto(s)

Azoles/química; Cobre/química; Compuestos de Sulfhidrilo/química; Catálisis; Ácidos Grasos/química; Oxidación-Reducción

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Sulfhidrilo / Azoles / Cobre Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2011 Tipo del documento: Article Pais de publicación: Reino Unido

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