Fungal allergen ß-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells.
Am J Respir Cell Mol Biol
; 45(6): 1133-41, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21642586
In addition to immune cells, airway epithelial cells can contribute to and shape the immune response in the lung by secreting specific cytokines. IL-6 is a key factor in determining the effector fate of CD4(+) T cells. Here we show that under basal conditions, the IL-6 gene is already highly expressed in lung epithelial cells, but not in immune cells resident in the lung. However, upon exposure of the lungs to fungal allergens, the direct contact of ß-glucans present in the fungus cell wall with lung epithelial cells is sufficient to trigger the rapid synthesis and secretion of IL-6 protein. This posttranscriptional regulation of IL-6 in response to fungal extracts is mediated by the p38 mitogen-activated protein kinase pathway. The inhalation of ß-glucans with a nonallergenic antigen is sufficient to provide an adjuvant effect that leads to mucous hyperplasia in the airways. Thus, ß-glucans may constitute a common determinant of the fungal and plant-derived allergens responsible for some of the pathological features in allergic asthma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspergillus fumigatus
/
Asma
/
Alérgenos
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Linfocitos T CD4-Positivos
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Regulación de la Expresión Génica
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Interleucina-6
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Mucosa Respiratoria
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Proteínas Quinasas p38 Activadas por Mitógenos
/
Beta-Glucanos
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Células Epiteliales
Límite:
Animals
Idioma:
En
Revista:
Am J Respir Cell Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos