[Compensation in behavioral disorders in rats receiving 5,7-DHT neonatally and by transplantation of embryonic raphe nucleus tissue]. / Kompensatsiia narushenii povedeniia krys, neonatal'no poluchavshikh 5,7-DOT, putem transplantatsii émbrional'noi tkani iader shva.
Zh Vyssh Nerv Deiat Im I P Pavlova
; 40(1): 156-64, 1990.
Article
en Ru
| MEDLINE
| ID: mdl-2162591
In 62 male Wistar rats the influence was studied of the transplanted embryonal tissue of raphe nuclei (NR) on the mechanisms of compensation of disturbances of exploratory activity, sensory attention, learning and emotional reactivity induced by neonatal injection of 5,7-DHT. In histochemical studies by Falk-Hillarp method the presence of yellow fluorescence confirmed the specificity of transplanted 5-HT neurones. It is found that NR transplantation causes in animals after 3 months recovery of orienting reaction to sensory stimuli, reduces rats reactivity in the open field, restores the ability to discrimination of emotionally positive influence, disturbed by neonatal injection of 5,7-DHT. The obtained data show the possibility of compensation of behaviour disturbances caused by chronic deprivation of 5-HT system activity by transplantation in the neocortex parenchyma of the embryonal tissue, containing serotoninergic neurones.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Núcleos del Rafe
/
5,7-Dihidroxitriptamina
/
Dihidroxitriptaminas
/
Tejido Nervioso
Límite:
Animals
Idioma:
Ru
Revista:
Zh Vyssh Nerv Deiat Im I P Pavlova
Asunto de la revista:
NEUROLOGIA
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Rusia