[Patients with mild cognitive impairment and a reduced CSF Aß1â42 protein progress rapidly to Alzheimer's disease]. / Pacientes con deterioro cognitivo leve y reducción de la proteína Aß(1-42) en LCR evolucionan rápidamente a enfermedad de Alzheimer.
Neurologia
; 27(1): 28-33, 2012 Jan.
Article
en Es
| MEDLINE
| ID: mdl-21621878
INTRODUCTION: Some studies have shown that CSF amyloid-beta 1-42 (Aß1â42), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau(181p)) proteins are useful diagnostic markers for distinguishing between clinically stable mild cognitive impairment (MCI) patients and those who will develop Alzheimers disease (AD). Our objective was to test the ability of this technique to discriminate in our cohort of MCI patients, according to the clinical outcome, one year after the lumbar puncture. MATERIAL AND METHODS: A total of 36 MCI patients were included from the local hospital memory clinic. Using INNO-BIA Alzbio-3 reagents from Innogenetics, we measured CSF Aß1â42, T-tau and P-tau(181p) proteins, and calculated the T-tau/Aß1â42 y P-tau(181p)/Aß1â42 ratios. This project was approved by the local ethics committee. RESULTS: One year after the lumbar puncture, 14 MCI patients (38%) developed AD. These patients had lower Aß1â42 protein levels (285.3 vs 377 ng/ml, P<.02) and higher P-tau(181p)/Aß1â42 ratio (0,25 vs 0,16, p<.02) than the clinically stable patients. CONCLUSIONS: Our MCI patients with lower Aß1â42 protein levels and an increased P-tau(181p) /Aß1â42 ratio progressed quickly to AD. These results may help to identify those MCI patients with a poorer prognosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
/
Disfunción Cognitiva
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Ethics
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Neurologia
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
Pais de publicación:
España