Growth-control of human ovarian-carcinoma cells by insulin-like growth-factors.

Bartlett, J M; Rabiasz, G J; Scott, W N; Langdon, S P; Hirst, G L; Lee, A; Smyth, J F; Miller, W R

Bartlett, J M; Rabiasz, G J; Scott, W N; Langdon, S P; Hirst, G L; Lee, A; Smyth, J F; Miller, W R.

Afiliación

Bartlett JM; WESTERN GEN HOSP,IMPERIAL CANC RES FUND,MED ONCOL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND. UNIV SURREY,SCH BIOL SCI,IMPERIAL CANC RES FUND,BREAST BIOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND.

Oncol Rep ; 2(5): 857-62, 1995 Sep.

Article en En | MEDLINE | ID: mdl-21597831

RESUMEN

The role of the insulin-like growth factors (IGFs) in 3 cultured human ovarian cancer cell lines (PEO1, PEO4, PEO14) was investigated. All three cell lines express mRNA for IGF-I and the PEO14 cell line expresses mRNA for IGF-II. Protein expression of IGF-II was demonstrated in the PEO14 and PEO4 cell lines. All 3 cell lines expressed mRNA for the IGF type I, IGF type II and insulin receptors; the presence of type I IGF receptors was confirmed by immuno-cytochemistry. IGF-I and insulin markedly stimulated the proliferation of PEO1 and PEO4 but not PEO14 cells while all 3 lines were insensitive to the addition of exogenous IGF-II.

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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 1995 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Grecia

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