Expression of tyrosine kinases encoding protooncogenes in differentiating human leukemia-cells.
Int J Oncol
; 4(5): 1029-34, 1994 May.
Article
en En
| MEDLINE
| ID: mdl-21567015
We investigated the expression of the tyrosine kinase encoding proto-oncogenes c-src and fyn during in vitro differentiation of the human promyelocytic leukemia cell line HL-60 and an HL-60 derived cell line (HL-GOT) with an altered T-cell receptor gene. In HL-60 cells, the fyn and c-src encoded tyrosine kinases are activated in a differentiation-dependent manner, whereas in HL-60T cells high levels of pp59(fyn) and pp60(c-src) specific kinase activities are already present in the untreated cells. From the data obtained we conclude that untreated HL-60T cells represent a more differentiated type of cells compared to the untreated promyelocytic HL-60 cells.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Int J Oncol
Asunto de la revista:
NEOPLASIAS
Año:
1994
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Grecia