Activation and effector functions of human RORC+ innate lymphoid cells.
Curr Opin Immunol
; 23(3): 361-7, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21561752
Innate lymphoid cells expressing the nuclear hormone receptor RORC have emerged as important players in human mucosal immunity. These cells combine innate modes of activation such as Toll-like receptor signaling with secretion of adaptive effector molecules including IL-2, BAFF and the Th17 cytokines IL-17 and IL-22. This endows these cells with the ability to rapidly respond to changes in cytokine milieu as well as changes in microbial composition and to affect both intestinal homeostasis and activation of adaptive immune cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos
/
Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido