Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.
Mech Ageing Dev
; 132(5): 249-56, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21549744
Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naïve T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study, PKCδ expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing ß-catenin dependent signalling in TECs contribute to the initiation of thymic senescence.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Transducción de Señal
/
Senescencia Celular
/
Células Epiteliales
/
Proteínas Wnt
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mech Ageing Dev
Año:
2011
Tipo del documento:
Article
País de afiliación:
Hungria
Pais de publicación:
Irlanda