Metabolic switching of human skeletal muscle cells in vitro.
Prostaglandins Leukot Essent Fatty Acids
; 85(5): 227-34, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21549583
In this review we will focus on external factors that may modify energy metabolism in human skeletal muscle cells (myotubes) and the ability of the myotubes to switch between lipid and glucose oxidation. We describe the metabolic parameters suppressibility, adaptability and substrate-regulated flexibility, and show the influence of nutrients such as fatty acids and glucose (chronic hyperglycemia), and some pharmacological agents modifying nuclear receptors (PPAR and LXR), on these parameters in human myotubes. Possible cellular mechanisms for changes in these parameters will also be highlighted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras Musculares Esqueléticas
/
Metabolismo Energético
/
Metabolismo de los Lípidos
/
Ácidos Grasos
/
Glucosa
Límite:
Humans
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Noruega
Pais de publicación:
Reino Unido