Efficient copper-catalyzed synthesis of poly-N-heterocycles containing amino acid residues.

Liu, Tao; Wang, Ruji; Yang, Haijun; Fu, Hua

Liu, Tao; Wang, Ruji; Yang, Haijun; Fu, Hua.

Afiliación

Liu T; Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, P R China.

Chemistry ; 17(24): 6765-71, 2011 Jun 06.

Article en En | MEDLINE | ID: mdl-21538622

RESUMEN

An efficient copper-catalyzed method has been developed for the synthesis of poly-N-heterocycles containing amino acid residues. The protocol uses readily available 2-halobenzamides containing amino acids and their methyl esters, substituted phenylacetonitriles, and malononitrile as the starting materials and the reactions were performed well under mild conditions. The method should provide a novel and useful strategy for synthesis of N-heterocyclic compounds.

Asunto(s)

Aminoácidos/química; Cobre/química; Compuestos Heterocíclicos/química; Compuestos Heterocíclicos/síntesis química; Hidantoínas/síntesis química; Hidrocarburos Halogenados/química; Quinolonas/síntesis química; Catálisis; Hidantoínas/química; Estructura Molecular; Quinolonas/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolonas / Cobre / Aminoácidos / Compuestos Heterocíclicos / Hidantoínas / Hidrocarburos Halogenados Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2011 Tipo del documento: Article Pais de publicación: Alemania

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