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The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase.
Ryazanova, Alexandra D; Alekseev, Alexander A; Slepneva, Irina A.
Afiliación
  • Ryazanova AD; Institute of Chemical Kinetics and Combustion, Laboratory of Chemistry and Physics of Free Radicals, Institutskaya 3, Novosibirsk, Russian Federation. razanova@kinetics.nsc.ru
J Enzyme Inhib Med Chem ; 27(1): 78-83, 2012 Feb.
Article en En | MEDLINE | ID: mdl-21534859
Phenoloxidase is a key enzyme of melanization catalyzing the oxidation of phenols. Phenylthiourea (PTU) is the well-known and widely used inhibitor of phenoloxidase. However, the mechanism of its action is not quite clear. In the present work, the effect of PTU on the enzymatic oxidation of 3-(3,4-dihydroxyphenyl)-l-alanine (DOPA) by phenoloxidase was studied by spectrophotometric methods. The inhibition constant of PTU was estimated as 0.21 ± 0.09 µM and the competitive type of inhibition was determined for this reaction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Feniltiourea / Dihidroxifenilalanina / Monofenol Monooxigenasa / Inhibidores Enzimáticos Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Feniltiourea / Dihidroxifenilalanina / Monofenol Monooxigenasa / Inhibidores Enzimáticos Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido