Hormone dependence of a mouse mammary tumor line induced in vivo by medroxyprogesterone acetate.
Breast Cancer Res Treat
; 17(1): 33-43, 1990 Nov.
Article
en En
| MEDLINE
| ID: mdl-2151368
The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in further in vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply; b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Neoplasias Mamarias Experimentales
/
Medroxiprogesterona
/
Neoplasias Hormono-Dependientes
Límite:
Animals
Idioma:
En
Revista:
Breast Cancer Res Treat
Año:
1990
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Países Bajos