Effect of ligand-activated estrogen receptor ß on lymphoma growth in vitro and in vivo.
Leukemia
; 25(7): 1103-10, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21502954
Estrogen receptor ß (ERß) is expressed in immune cells and studies have suggested an antiproliferative function of ERß. We detected ERß expression in murine T- and human B-cell lymphoma cell lines and analyzed the effects of estradiol and selective ERß agonists on lymphoma growth in culture and in vivo. Treating the cells with estradiol had minor effects on cell growth, whereas the selective ERß agonists diarylpropionitrile (DPN) and KB9520 showed a strong antiproliferative effect. When grafting mice with murine T-cell lymphoma cells, male mice developed larger tumors compared with female mice, a difference that was abolished following ovariectomy, showing estrogen-dependent growth in vivo. To investigate whether lymphoma growth may be inhibited in vivo by ERß agonist treatment, mice grafted with murine lymphoma cells were treated with DPN or KB9520. Both ERß-selective agonists strongly inhibited lymphoma growth. The reduced tumor size seen following either DPN or KB9520 treatment was due to reduced proliferation and increased apoptosis. Our results show an ERß ligand-dependent antiproliferative effect of lymphoma cells expressing endogenous ERß and that lymphoma cell growth in vivo can efficiently be inhibited by ERß agonists. This suggests that ERß agonists may be useful in the treatment of lymphomas.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propionatos
/
Linfoma de Células T
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Linfoma de Burkitt
/
Antineoplásicos Hormonales
/
Receptor beta de Estrógeno
/
Proteínas de Neoplasias
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Neoplasias Hormono-Dependientes
/
Nitrilos
Límite:
Animals
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Leukemia
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2011
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido