Photodynamic therapy in the management of pre-malignant head and neck mucosal dysplasia and microinvasive carcinoma.
Photodiagnosis Photodyn Ther
; 8(2): 75-85, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21497298
The management of head and neck mucosal dysplasia and microinvasive carcinoma is an appealing strategy to prevent the development of invasive carcinomas. While surgery remains the standard of care, photodynamic therapy (PDT) offers several advantages including the ability to provide superficial yet wide field mucosal ablative treatment. This is particularly attractive where defining the extent of the dysplasia can be difficult. PDT can also retreat the mucosa without any cumulative fibrotic complications affecting function. To date, clinical experience suggests that this treatment approach can be effective in obtaining a complete response for the treated lesion but long term follow-up is limited. Further research efforts are needed to define not only the risk of malignant transformation with PDT but also to develop site specific treatment recommendations that include the fluence, fluence rate and light delivery technique.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Lesiones Precancerosas
/
Fármacos Fotosensibilizantes
/
Neoplasias de Células Escamosas
/
Neoplasias de Cabeza y Cuello
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Photodiagnosis Photodyn Ther
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos