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RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima.
Grudzinska, Monika K; Bojakowski, Krzysztof; Soin, Joanna; Stassen, Frank; Söderberg-Nauclér, Cecilia; Religa, Piotr.
Afiliación
  • Grudzinska MK; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Bojakowski K; Department of General, Vascular and Oncologic Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Soin J; Department of General Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.
  • Stassen F; Maastricht University Medical Center, Maastricht, The Netherlands.
  • Söderberg-Nauclér C; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Religa P; Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Herpesviridae ; 1(1): 7, 2010 Dec 23.
Article en En | MEDLINE | ID: mdl-21429242
BACKGROUND: Cytomegalovirus (CMV) infection has been associated with accelerated transplant vasculopathy. In this study, we assessed the effects of acute rat CMV (RCMV) infection on vessel remodeling in transplant vasculopathy, focusing on allograft morphology, inflammation and contribution of adventitial cells to intimal hyperplasia. METHODS: Infrarenal aorta was locally infected with RCMV and transplanted from female F344 rats to male Lewis rats. Graft samples were collected 2 and 8 weeks after transplantation and analyzed for intimal hyperplasia, collagen degradation and inflammation. Transplantation of aorta followed by transplantation of RCMV infected and labeled isogenic adventitia were performed to study migration of adventitial cells towards the intima. RESULTS: Intimal hyperplasia was increased threefold in infected allografts. RCMV induced apoptosis in the media, expression of matrix metalloproteinase 2, and decreased collagen deposits. Macrophage infiltration was increased in the infected allografts and resulted in increased production of MCP-1. RCMV-infected macrophages were observed in the adventitia and intima. Cells derived from infected adventitia migrated towards the intima of the allograft. CONCLUSIONS: RCMV enhances infiltration of macrophages to the allografts, and thereby increases MCP-1 production and inflammation, followed by recruitment of adventitial cells to the intima and accelerated intimal hyperplasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Herpesviridae Año: 2010 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Herpesviridae Año: 2010 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido