Axonal damage in multiple sclerosis.
Mt Sinai J Med
; 78(2): 231-43, 2011.
Article
en En
| MEDLINE
| ID: mdl-21425267
Multiple sclerosis is a debilitating disease of the central nervous system that has been characteristically classified as an immune-mediated destruction of myelin, the protective coating on nerve fibers. Although the mechanisms responsible for the immune attack to central nervous system myelin have been the subject of intense investigation, more recent studies have focused on the neurodegenerative component, which is cause of clinical disability in young adults and appears to be only partially controlled by immunomodulatory therapies. Here, we review distinct, but not mutually exclusive, mechanisms of pathogenesis of axonal damage in multiple sclerosis patients that are either consequent to long-term demyelination or independent from it. We propose that the complexity of axonal degeneration and the heterogeneity of the underlying pathogenetic mechanisms should be taken into consideration for the design of targeted therapeutic intervention.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Axones
/
Factores Inmunológicos
/
Esclerosis Múltiple
/
Vaina de Mielina
/
Degeneración Nerviosa
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Mt Sinai J Med
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos