Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years.

Steiner, Anne Z; Herring, Amy H; Kesner, James S; Meadows, Juliana W; Stanczyk, Frank Z; Hoberman, Steven; Baird, Donna D

Steiner, Anne Z; Herring, Amy H; Kesner, James S; Meadows, Juliana W; Stanczyk, Frank Z; Hoberman, Steven; Baird, Donna D.

Afiliación

Steiner AZ; From the Departments of Obstetrics and Gynecology and Biostatistics, University of North Carolina, Chapel Hill, North Carolina; the National Institute for Occupational Safety and Health, Cincinnati, Ohio; the Department of Obstetrics and Gynecology and Preventive Medicine, University of Southern California, Los Angeles, California; and the Epidemiology Branch, National Institute of Environmental Health Science/National Institutes of Health, Research Triangle Park, North Carolina.

Obstet Gynecol ; 117(4): 798-804, 2011 Apr.

Article en En | MEDLINE | ID: mdl-21422850

RESUMEN

OBJECTIVE: To generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging. METHODS: Women aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months provided early-follicular phase serum and urine (N=100). Subsequently, these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. Serum was analyzed for estradiol, follicle-stimulating hormone (FSH), antimüllerian hormone, and inhibin B. Urine was analyzed for FSH and estrone 3-glucuronide. Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios. RESULTS: Sixty-three percent of participants conceived within 6 months. After adjusting for age, 18 women (18%) with serum antimüllerian hormone levels of 0.7 ng/mL or less had significantly reduced fecundability given intercourse on a fertile day compared with women with higher antimüllerian hormone levels (fecundability ratio 0.38; 95% confidence interval [CI] 0.08-0.91). The day-specific fecundability for women with early-follicular phase serum FSH values greater than 10 milli-international units/mL compared with women with lower FSH levels was also reduced, although nonsignificantly (11% of women affected; fecundability ratio 0.44; 95% CI 0.08-1.10). The association with urinary FSH was weaker (27% women affected; fecundability ratio 0.61; 95% CI 0.26-1.26), and the associations for the other markers were weaker still. CONCLUSION: Early-follicular phase antimüllerian hormone appears to be associated with natural fertility in the general population. LEVEL OF EVIDENCE: II.

Asunto(s)

Hormona Antimülleriana/sangre; Estradiol/sangre; Hormona Folículo Estimulante/sangre; Inhibinas/sangre; Edad Materna; Adulto; Biomarcadores/sangre; Estudios de Cohortes; Intervalos de Confianza; Femenino; Fertilidad/fisiología; Humanos; Valor Predictivo de las Pruebas; Embarazo; Índice de Embarazo; Factores de Riesgo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edad Materna / Estradiol / Hormona Antimülleriana / Hormona Folículo Estimulante / Inhibinas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Obstet Gynecol Año: 2011 Tipo del documento: Article Pais de publicación: Estados Unidos

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