HSV Vectors for Gene Therapy.
Methods Mol Med
; 10: 369-86, 1998.
Article
en En
| MEDLINE
| ID: mdl-21374242
A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are 1 Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1); 2 Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2), and 3. Nonreplicating HSV recombinants can establish a latent infection efficiently (3).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Methods Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Estados Unidos