Correction of ß654-thalassaemia mice using direct intravenous injection of siRNA and antisense RNA vectors.

Xie, Shu-Yang; Li, Wei; Ren, Zhao-Rui; Huang, Shu-Zhen; Zeng, Fanyi; Zeng, Yi-Tao

Xie, Shu-Yang; Li, Wei; Ren, Zhao-Rui; Huang, Shu-Zhen; Zeng, Fanyi; Zeng, Yi-Tao.

Afiliación

Xie SY; Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, People's Republic of China.
Li W; Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, People's Republic of China.
Ren ZR; Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, People's Republic of China.
Huang SZ; Key Lab of Medical Embryo Molecular Biology, Ministry of Health, China, Shanghai Lab of Embryo and Reproduction Engineering, Shanghai, People's Republic of China.
Zeng F; Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Road, Shanghai, 200040, People's Republic of China.
Zeng YT; Key Lab of Medical Embryo Molecular Biology, Ministry of Health, China, Shanghai Lab of Embryo and Reproduction Engineering, Shanghai, People's Republic of China.

Int J Hematol ; 93(3): 301-310, 2011 Mar.

Article en En | MEDLINE | ID: mdl-21369857

Asunto(s)

Vectores Genéticos/farmacología; Plásmidos/farmacología; ARN sin Sentido/farmacología; ARN Interferente Pequeño/farmacología; Globinas alfa/biosíntesis; Globinas beta/biosíntesis; Talasemia beta/terapia; Animales; Células de la Médula Ósea/metabolismo; Regulación hacia Abajo/efectos de los fármacos; Regulación hacia Abajo/genética; Vectores Genéticos/genética; Células HeLa; Hematopoyesis Extramedular/efectos de los fármacos; Hematopoyesis Extramedular/genética; Humanos; Ratones; Ratones Mutantes; Plásmidos/genética; Empalme del ARN/efectos de los fármacos; Empalme del ARN/genética; ARN sin Sentido/genética; ARN Interferente Pequeño/genética; Globinas alfa/genética; Globinas beta/genética; Talasemia beta/genética; Talasemia beta/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásmidos / ARN sin Sentido / Talasemia beta / ARN Interferente Pequeño / Globinas alfa / Globinas beta / Vectores Genéticos Límite: Animals / Humans Idioma: En Revista: Int J Hematol Asunto de la revista: HEMATOLOGIA Año: 2011 Tipo del documento: Article Pais de publicación: Japón

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