Essential fatty acid status in teenage girls with eating disorders and weight loss.
Acta Paediatr
; 100(5): 762-7, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21362034
AIM: To explore the relationship between essential fatty acids (FA) and weight changes in adolescent girls with eating disorders (ED). METHODS: Blood samples were obtained from 220 girls with ED and 39 healthy controls. The girls with ED were 15.3 ± 1.5 years of age and weighed 49.8 ± 8.7 kg (BMI 18.3 ± 2.8 kg/m(2)) after a weight loss of 6.8 ± 6.4 kg. FA were analysed in plasma phospholipids (PPL) and erythrocyte membranes (ERY). RESULTS: The proportions of saturated and monounsaturated FA were increased during weight loss, while linoleic acid (18:2ω6) was decreased. The proportions of eicosapentanoic acid (EPA) (20:5ω3) and docosahexanoic acid (DHA) (22:6ω3) in PPL and ERY did not differ from controls. The activity of stearoyl-CoA-desaturase was increased as evidenced by an increased product/precursor ratio and correlated with the rate of weight loss. The activities of delta-6-desaturase and delta-5-desaturase did not differ from controls. The rate of weight loss was inversely correlated with delta-6-desaturase and directly correlated with delta-5-desaturase. CONCLUSION: The FA profile indicates low-fat intake, fat mobilization from stores and an increased conversion of essential FA at the delta-5-desaturase step during weight loss in adolescent girls with ED. Normal levels of EPA and DHA were maintained.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Esenciales
/
Pérdida de Peso
/
Trastornos de Alimentación y de la Ingestión de Alimentos
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Female
/
Humans
Idioma:
En
Revista:
Acta Paediatr
Año:
2011
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Noruega