[Study on the anti-tumor effect of paclitaxel mixed micelle by using in vivo optical imaging technique].
Yao Xue Xue Bao
; 45(4): 530-4, 2010 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-21355223
In vivo tumor imaging technique method based on bioluminescence principle was established to evaluate the anti-tumor effect of paclitaxel mixed micelle (PMM). MDA-MB-231 tumor cells with luciferase reporter vectors were firstly implanted into nude mice, and subsequently the luciferase substrate was regularly injected during intraperitoneal administration of PMM. Then the tumor size, growth and the intensity of light signals were monitored with in vivo imaging technique. The method of luciferase tumor in vivo imaging could be real-time, reliable and exact in labeling and reflecting the growth of tumors, and the observed results were consistent with that by conventional method, so it would be a feasible approach to study anti-tumor effect of drugs. The anti-tumor effect of paclitaxel mixed micelle was observed by this method, and the results showed that this formulation could inhibit growth of tumor, and the anti-tumor rate of it was about 85%.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanoma Experimental
/
Neoplasias de la Mama
/
Paclitaxel
/
Antineoplásicos Fitogénicos
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China