[Testicular dysgenesis syndrome: an update].
Zhonghua Nan Ke Xue
; 16(12): 1113-6, 2010 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-21348205
Researches on the testicular dysgenesis syndrome (TDS) have flourished in the recent decade, and a widely accepted view on its pathogenesis is that environmental endocrine disrupting chemicals (EDCs) act on Leydig cells and/or testicular Sertoli cells, resulting in abnormal development of the testis and leading to the symptoms of TDS. Molecular biological studies suggest a correlation of TDS etiology with insulin-like factor 3 (INSL-3), androgen receptor (AR), P27kip, WT-1 and Müllerian inhibiting substance (MIS). This review focuses on the progress in current researches on the etiology and mechanism of TDS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Testiculares
/
Disgenesia Gonadal
Tipo de estudio:
Etiology_studies
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China