Experimental chronic interstitial pancreatitis induced by scorpion toxin in rats.

Novaes, G; Cardozo, C de C; Costa, N M; de Falco, C N; de Carvalho, M H; de Queiroz, A C

Novaes, G; Cardozo, C de C; Costa, N M; de Falco, C N; de Carvalho, M H; de Queiroz, A C.

Afiliación

Novaes G; Department of Physiology, Federal University of Bahia, Salvador, BA.

Arq Gastroenterol ; 27(4): 187-90, 1990.

Article en En | MEDLINE | ID: mdl-2133193

RESUMEN

Scorpion venom effects in the gastrointestinal system have been investigated both in men and experimental animals. Pancreatic flux and enzyme content are increased by TsTX, the purified venom from the scorpion Tityus serrulatus. In this study male rats received a single intravenous injection of TsTX. They were sacrificed 20 days later and their pancreas removed. Histopathological studies showed interstitial fibrosis, mononuclear infiltrate, acinar atrophy and ductal dilatation. There also appeared, although less frequently, eosinophil infiltrates, ductular hyperplasia and dense eosinophilic secretion in enlarged ducts. All lesions were multifocal. Islet hyperplasia and nesidioblastosis were also observed.

Asunto(s)

Pancreatitis/inducido químicamente; Venenos de Escorpión/toxicidad; Animales; Enfermedad Crónica; Inyecciones Intravenosas; Masculino; Pancreatitis/patología; Pancreatitis/fisiopatología; Ratas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Venenos de Escorpión Límite: Animals Idioma: En Revista: Arq Gastroenterol Año: 1990 Tipo del documento: Article Pais de publicación: Brasil

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