[Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].
Bioorg Khim
; 36(6): 832-40, 2010.
Article
en Ru
| MEDLINE
| ID: mdl-21317950
The synthesis of a new group of maleopimaric acid amides containing fragments of the methyl esters of amino acids, aliphatic amines, imidazole and N-methylpiperazine was carried out. Ozonolysis of methyl maleopimarate flows through the cleavage of double bond C18(19) and the disclosure of anhydrous cycle with formation of secotriacid. As a result of screening of anti-inflammatory and antiulcer activity of maleopimaric acid derivatives new effective compounds such as methyl esters of maleopimaric acid and product of ozonolysis - diterpenic secotriacid, maleopimaric acid amide with L-leucine were revealed. An important advantage of the compounds studied is the low toxicity and the presence of bidirectional activity in the absence of adverse effects on the animal.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ozono
/
Triterpenos
/
Amidas
Idioma:
Ru
Revista:
Bioorg Khim
Año:
2010
Tipo del documento:
Article
Pais de publicación:
Rusia