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The effect of exemestane, anastrozole, and tamoxifen on lipid profiles in Japanese postmenopausal early breast cancer patients: final results of National Surgical Adjuvant Study BC 04, the TEAM Japan sub-study.
Hozumi, Y; Suemasu, K; Takei, H; Aihara, T; Takehara, M; Saito, T; Ohsumi, S; Masuda, N; Ohashi, Y.
Afiliación
  • Hozumi Y; Department of Breast and General Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan. y-hozumi@jichi.ac.jp
Ann Oncol ; 22(8): 1777-82, 2011 Aug.
Article en En | MEDLINE | ID: mdl-21285133
BACKGROUND: In this Tamoxifen Exemestane Adjuvant Multinational Japan sub-study, we evaluated the time course of changes in serum lipids in postmenopausal women with hormone-sensitive early breast cancer treated with exemestane, anastrozole, or tamoxifen for postoperative adjuvant therapy. PATIENTS AND METHODS: A total of 154 breast cancer patients were assigned to receive exemestane, anastrozole, or tamoxifen in this randomized open-label study. Serum lipid parameters including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured during 1 year of treatment. RESULTS: TC and LDL-C rapidly decreased in patients treated with tamoxifen at 3 months. Compared with anastrozole and exemestane patients, TC and LDL-C were significantly lower at all assessment time points in tamoxifen patients (P < 0.05). TG increased in tamoxifen patients; it was significantly higher compared with exemestane patients at all assessment time points (P < 0.05). HDL-C slightly decreased in exemestane patients; it was significantly lower compared with anastrozole patients at 3 months and 1 year (P = 0.0179 and 0.0013, respectively). CONCLUSION: Changes of lipid profiles in Japanese postmenopausal women treated with tamoxifen were relatively favorable, while exemestane and anastrozole had no clinically significant effect on the serum lipids.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Triazoles / Neoplasias de la Mama / Androstadienos / Lípidos / Neoplasias Hormono-Dependientes / Nitrilos Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2011 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Triazoles / Neoplasias de la Mama / Androstadienos / Lípidos / Neoplasias Hormono-Dependientes / Nitrilos Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2011 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido