Thyroid function in fragile-X syndrome males.

Bregman, J D; Leckman, J F; Ort, S I

Bregman, J D; Leckman, J F; Ort, S I.

Afiliación

Bregman JD; Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06510.

Yale J Biol Med ; 63(4): 293-9, 1990.

Article en En | MEDLINE | ID: mdl-2125773

RESUMEN

Twelve males with fragile-X syndrome between the ages of three and 28 years underwent assessment of thyroid function. All 12 subjects demonstrated normal baseline values for thyroid stimulating hormone (TSH), thyroxine, thyroid binding globulin (TBG), and estimated free thyroxine (EFT). Relative to a control group reported in the literature, however, the fragile-X subjects exhibited a blunted TSH response to thyrotropin releasing hormone (TRH). This finding suggests the presence of subtle dysfunction within the hypothalamic-pituitary-thyroid axis. Elevated baseline prolactin levels were also observed among the fragile-X subjects. These results support previous reports of hypothalamic-pituitary abnormalities among fragile-X syndrome males.

Asunto(s)

Síndrome del Cromosoma X Frágil/fisiopatología; Glándula Tiroides/metabolismo; Hormonas Tiroideas; Adolescente; Adulto; Proteínas Portadoras/metabolismo; Niño; Preescolar; Humanos; Masculino; Proteínas de la Membrana/metabolismo; Hipófisis/metabolismo; Prolactina/metabolismo; Pruebas de Función de la Tiroides; Tirotropina/metabolismo; Hormona Liberadora de Tirotropina/metabolismo; Tiroxina/metabolismo; Proteínas de Unión a Hormona Tiroide

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Hormonas Tiroideas / Síndrome del Cromosoma X Frágil Límite: Adolescent / Adult / Child / Child, preschool / Humans / Male Idioma: En Revista: Yale J Biol Med Año: 1990 Tipo del documento: Article Pais de publicación: Estados Unidos

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