[Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(1): 26-8, 2011 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-21251382
OBJECTIVE: To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children. METHODS: A total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each): placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment. RESULTS: The effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05). CONCLUSIONS: Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenilpropanolamina
/
Compuestos de Bencidrilo
/
Antagonistas Muscarínicos
/
Cresoles
/
Vejiga Urinaria Hiperactiva
/
Ácidos Mandélicos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2011
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China