Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus.

Bandyopadhyay, Prabal; Guha, Lopamudra; Seenivasagan, T; Sathe, Manisha; Sharma, Pratibha; Parashar, B D; Kaushik, M P

Bandyopadhyay, Prabal; Guha, Lopamudra; Seenivasagan, T; Sathe, Manisha; Sharma, Pratibha; Parashar, B D; Kaushik, M P.

Afiliación

Bandyopadhyay P; Defence R & D Establishment, Jhansi Road, Gwalior 474 002 (M.P.), India.

Bioorg Med Chem Lett ; 21(2): 794-7, 2011 Jan 15.

Article en En | MEDLINE | ID: mdl-21193312

RESUMEN

A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10µgml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.

Asunto(s)

Aedes/fisiología; Hidrazonas/química; Hidrazonas/metabolismo; Oviposición; Aedes/metabolismo; Animales; Dengue/prevención & control; Ésteres/síntesis química; Ésteres/química; Ésteres/metabolismo; Femenino; Hidrazonas/síntesis química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oviposición / Aedes / Hidrazonas Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2011 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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