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Genomic signatures of diet-related shifts during human origins.
Babbitt, Courtney C; Warner, Lisa R; Fedrigo, Olivier; Wall, Christine E; Wray, Gregory A.
Afiliación
  • Babbitt CC; Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. courtney.babbitt@duke.edu
Proc Biol Sci ; 278(1708): 961-9, 2011 Apr 07.
Article en En | MEDLINE | ID: mdl-21177690
There are numerous anthropological analyses concerning the importance of diet during human evolution. Diet is thought to have had a profound influence on the human phenotype, and dietary differences have been hypothesized to contribute to the dramatic morphological changes seen in modern humans as compared with non-human primates. Here, we attempt to integrate the results of new genomic studies within this well-developed anthropological context. We then review the current evidence for adaptation related to diet, both at the level of sequence changes and gene expression. Finally, we propose some ways in which new technologies can help identify specific genomic adaptations that have resulted in metabolic and morphological differences between humans and non-human primates.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hominidae / Evolución Biológica Límite: Animals / Humans Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hominidae / Evolución Biológica Límite: Animals / Humans Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido