Anticytokine therapy in preterm labor: current knowledge and future perspectives.
Gynecol Obstet Invest
; 71(1): 1-10, 2011.
Article
en En
| MEDLINE
| ID: mdl-21160188
AIMS: Up to 10% of pregnant women have preterm birth that might be refractory to current therapy. Infections and asphyxia related to preterm birth are the causes of death in the majority of neonates and therefore represent an urgent clinical need. METHODS: The present article reviews the English language literature for preclinical and clinical trials and promising molecular targets on preterm labor. RESULTS: Preterm birth is a complex heterogeneous condition. There is no current treatment for the fetal membranes once they have ruptured; therefore, essentially any treatment has to be preventative to quiesce preterm labor and prevent any spread of infection to the fetus. Modulating the pro-inflammatory process-mediated cytokine network may present a new paradigm for preterm labor treatment. There are many reports on the role of ß-adrenergic agonists (betamimetics), magnesium sulfate, progesterone, oxytocin antagonist, calcium channel blocker or the Kunitz inhibitor bikunin in the treatment of preterm labor. In the present review, we have focused on the preclinical and clinical anticytokine therapy for preterm labor. The preclinical and clinical trials with bikunin reducing preterm labor exacerbations have raised the importance of usefulness and safety considerations related to this novel therapy. CONCLUSION: Anticytokine therapy is ready for the clinic.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Citocinas
/
Trabajo de Parto Prematuro
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Gynecol Obstet Invest
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Suiza