[Flecainide poisoning]. / Intoxicación por flecainida.
Rev Esp Anestesiol Reanim
; 57(9): 596-8, 2010 Nov.
Article
en Es
| MEDLINE
| ID: mdl-21155342
Flecainide is an antiarrhythmic drug that blocks sodium channels during phase 0 of cardiac action potential, delaying conduction and reducing contractility. Intoxication by this drug is rare. Onset of effect, which is rapid, takes the form of hypotension and cardiac arrhythmias; mortality is high. No antidote is available and management is based on the few cases that have been reported. The metabolism of flecainide is affected by both kidney and liver failure, which lead to accumulation of the drug. Flecainide should not be used in patients with such failure unless the potential benefits clearly outweigh the risks. If flecainide is prescribed, diligent clinical, electrocardiographic, and hemodynamic vigilance is imperative and plasma levels of the drug should be monitored. We report a case of flecainide poisoning in which the drug was prescribed to treat atrial fibrillation in a woman with resolving sepsis with renal and hepatic complications.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Flecainida
/
Bloqueadores de los Canales de Sodio
/
Complicaciones Intraoperatorias
Tipo de estudio:
Etiology_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
Es
Revista:
Rev Esp Anestesiol Reanim
Año:
2010
Tipo del documento:
Article
Pais de publicación:
España