Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.
Eur J Med Chem
; 46(1): 439-46, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-21111517
A novel ester of hydroxytyrosol and α-lipoic acid was synthesized in satisfactory yield by original and simple procedures and evaluated about its antiproliferative activity on the human colorectal adenocarcinoma HT-29 cell line. The compound exhibited a cell growth inhibitory activity significantly more potent than the corresponding parent natural compounds, very likely due to the induction of cell cycle arrest in the G2/M phase. These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and α-lipoic acid.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alcohol Feniletílico
/
Ácido Tióctico
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Neoplasias del Colon
Límite:
Humans
Idioma:
En
Revista:
Eur J Med Chem
Año:
2011
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Francia