Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sß Thalassemia) without Other Known Causes of Hepatic Disease.
Case Rep Gastroenterol
; 3(3): 275-279, 2009 Sep 12.
Article
en En
| MEDLINE
| ID: mdl-21103241
Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15-30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many transfusions received by these patients in their lifetime. Thus, cirrhosis has been described almost exclusively in patients with sickle cell anemia, while only mild liver abnormalities have been associated with the sickle cell trait. In the present case study, we describe a young Mediterranean man carrying a sickle cell trait (Hb Sß(+) thalassemia) who developed liver cirrhosis being negative for hepatitis C and B viruses or for other causes of cirrhosis and not receiving chronic blood transfusions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Case Rep Gastroenterol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Suiza