A prospective study of alcohol consumption and HIV acquisition among injection drug users.
AIDS
; 25(2): 221-8, 2011 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-21099668
OBJECTIVE: to estimate the effect of alcohol consumption on HIV acquisition while appropriately accounting for confounding by time-varying risk factors. DESIGN: african-American injection drug users in the AIDS Link to Intravenous Experience cohort study. Participants were recruited and followed with semiannual visits in Baltimore, Maryland between 1988 and 2008. METHODS: marginal structural models were used to estimate the effect of alcohol consumption on HIV acquisition. RESULTS: at entry, 28% of 1525 participants were women with a median (quartiles) age of 37 (32-42) years and 10 (10-12) years of formal education. During follow-up, 155 participants acquired HIV and alcohol consumption was 24, 24, 26, 17, and 9% for 0, 1-5, 6-20, 21-50, and 51-140 drinks per week over the prior 2 years, respectively. In analyses accounting for sociodemographic factors, drug use, and sexual activity, hazard ratios for participants reporting 1-5, 6-20, 21-50, and 51-140 drinks per week in the prior 2 years compared to participants who reported 0 drinks per week were 1.09 (0.60-1.98), 1.18 (0.66-2.09), 1.66 (0.94-2.93), and 2.12 (1.15-3.90), respectively. A trend test indicated a dose-response relationship between alcohol consumption and HIV acquisition (P value for trend = 9.7 × 10). CONCLUSION: a dose-response relationship between alcohol consumption and subsequent HIV acquisition is indicated, independent of measured known risk factors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Sexual
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Negro o Afroamericano
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Consumo de Bebidas Alcohólicas
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Infecciones por VIH
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Abuso de Sustancias por Vía Intravenosa
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VIH-1
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido