Degree of immobilization of synthetic RGDS(PO(3)H(2))PA peptides on titanium surfaces.
Dent Mater J
; 29(6): 668-72, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21099158
The purpose of this study was to characterize the chemical interaction between titanium surfaces and the peptide RGDS(PO(3)H(2))PA (P-RGD) synthesized from RGD peptide (RGD) and o-phospho-L-serine (P-Ser), and to determine the degree of peptide immobilization on the titanium surface. X-ray photoelectron spectroscopy showed that the adsorption amount of RGD was significantly smaller than those of P-Ser and P-RGD (p<0.05). Furthermore, although it appeared that P-RGD bonded to the surface, ultrasonic rinsing with water caused it to dissociate, releasing RGD and leaving only S(PO(3)H(2))PA bonded to the surface. These findings show that although it remains difficult to obtain a stable P-RGD layer, the phosphate functional group greatly improves immobilization of the molecule on titanium surfaces.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Fosfoserina
/
Titanio
/
Fibronectinas
/
Materiales Dentales
/
Proteínas Inmovilizadas
Límite:
Humans
Idioma:
En
Revista:
Dent Mater J
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón