Apolipoprotein E genotype and concussion in college athletes.
Clin J Sport Med
; 20(6): 464-8, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21079443
OBJECTIVE: To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We hypothesized that carrying 1 or more APOE rare (or minor) allele assessed in this study would be associated with having a history of 1 or more concussions. DESIGN: Multicenter cross-sectional study. SETTING: University athletic facilities. PARTICIPANTS: One hundred ninety-six male football (n = 163) and female soccer (n = 33) college athletes volunteered. INTERVENTIONS: Written concussion history questionnaire and saliva samples for genotyping. MAIN OUTCOME MEASURES: Self-reported history of a documented concussion and rare APOE genotype (E2, E4, promoter). RESULTS: There was a significant association (Wald χ² = 3.82; P = 0.05; odds ratio = 9.8) between carrying all APOE rare alleles and the history of a previous concussion. There was also a significant association (Wald χ² = 3.96, P = 0.04, odds ratio = 8.4) between carrying the APOE promoter minor allele and experiencing 2 or more concussions. CONCLUSIONS: Carriers of all 3 APOE rare (or minor) alleles assessed in this study were nearly 10 times more likely to report a previous concussion and may be at a greater risk of concussion versus noncarriers. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions and may be at a greater risk of multiple concussions versus noncarriers. Research involving larger samples of individuals with multiple concussions and carriers of multiple APOE rare alleles is warranted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos en Atletas
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Fútbol
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Conmoción Encefálica
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Apolipoproteína E2
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Apolipoproteína E4
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Fútbol Americano
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Clin J Sport Med
Asunto de la revista:
MEDICINA ESPORTIVA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos