[Age-related features of immunocompetent cells of human placenta associated with diabetes mellitus].
Adv Gerontol
; 23(2): 208-12, 2010.
Article
en Ru
| MEDLINE
| ID: mdl-21033374
The immune-competent cells of placenta play the important role in protection of developing fetus against infectious agents; but their dysfunction can lead to development of placental insufficiency that affects health both fetus and mother. The aim of this study was the comparative analysis of presence of immune competent cells in villous chorion of mature placenta, taken from women with diabetes of different age groups. In our study we found three subpopulations of immune cells in villous chorion of mature placenta: natural killer cells (NK), B-lymphocytes and macrophages. Prevailing subpopulation are macrophages, they are detected 1,8 times more often than B-lymphocytes, and 2,3 times more often than NK. The quantity of immune competent cells in groups with diabetes of various types is different. Thus, the greatest number of macrophages was detected in group with diabetes type II of middle age (29-35 years)-- 4.62 +/- 0.93%, B-lymphocytes in group of women with diabetes type I of younger age (18-28 years)--2.50 +/- 0.30%, NK-cells in group with diabetes type I of younger age--1.98 +/- 0,42%. Analysis of received data showed the differences in expression of markers of immune cells in women of different age groups, which brings about the conclusion of various reactance of immune system of women with diabetes depending on age.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Embarazo en Diabéticas
/
Envejecimiento
/
Diabetes Gestacional
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Ru
Revista:
Adv Gerontol
Asunto de la revista:
GERIATRIA
Año:
2010
Tipo del documento:
Article
Pais de publicación:
Rusia