Caffeic acid esters and lignans from Piper sanguineispicum.
J Nat Prod
; 73(11): 1884-90, 2010 Nov 29.
Article
en En
| MEDLINE
| ID: mdl-20954722
Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC(50) 2.0 and 1.8 µM, respectively) with moderate cytotoxicity on murine macrophages.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Cafeicos
/
Lignanos
/
Citotoxinas
/
Piper
/
Leishmania
/
Macrófagos
Límite:
Animals
País/Región como asunto:
America do sul
/
Peru
Idioma:
En
Revista:
J Nat Prod
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos