Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage?
World Neurosurg
; 73(6): 646-53, 2010 Jun.
Article
en En
| MEDLINE
| ID: mdl-20934152
INTRODUCTION: Statins have been studied in patients with aneurysmal subarachnoid hemorrhage (SAH) but the history, pharmacology, and studies have not been reviewed recently. METHODS: The development of statins as well as their biological effects and pharmacology are reviewed. Recent clinical studies in patients with SAH are summarized. RESULTS: Statins lower serum cholesterol but they also have antioxidant, anti-inflammatory, vasodilatory, angiogenic, neuroprotective, vasoprotective, and endothelial preserving actions. In patients with SAH, they may decrease the incidence of symptomatic vasospasm, although the effects on overall outcome are less clear. They should be continued in patients who are taking them on admission and perhaps initiated in those who have indications for them. Side effects are rare. CONCLUSION: A large randomized, double-blind clinical trial is needed before it can be determined that statins are beneficial for patients with aneurysmal SAH.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hemorragia Subaracnoidea
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Vasoespasmo Intracraneal
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
World Neurosurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos