Impact of opium on the serum levels of TGF-ß in diabetic, addicted and addicted-diabetic rats.
Iran J Immunol
; 7(3): 186-92, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20876989
BACKGROUND: Several cells of immune system such as regulatory T cells and macrophages secrete transforming growth factor-ß (TGF-ß) in response to different stimuli. This cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders. OBJECTIVE: The aim of this study was to evaluate the influence of opium addiction on serum level of TGF-ß in male and female diabetic and non-diabetic Wistar rats. METHODS: This experimental study was performed on normal, opium addicted, diabetic and addicted-diabetic male and female rats. Serum level of TGF-ß was measured by ELISA. RESULTS: The results of our study indicated that the mean serum level of TGF-ß in female addicted rats was significantly increased compared to control group (p<0.004). Conversely, in male addicted rats the mean serum level of TGF-ß was lower compared with control (p<0.065). CONCLUSION: Our results suggest that opium and its derivatives have differential inductive effects on the cytokine expression in male and female rats.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Opio
/
Factor de Crecimiento Transformador beta
/
Diabetes Mellitus
/
Diabetes Mellitus Experimental
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Trastornos Relacionados con Opioides
/
Narcóticos
Límite:
Animals
Idioma:
En
Revista:
Iran J Immunol
Año:
2010
Tipo del documento:
Article
Pais de publicación:
Irán