The total synthesis of (±)-fumimycin.
Chemistry
; 16(42): 12660-7, 2010 Nov 08.
Article
en En
| MEDLINE
| ID: mdl-20859963
The antibiotic agent fumimycin has been synthesized for the first time. This natural product was found to inhibit the bacterial peptide deformylase and may represent a lead structure to a class of novel antibacterials. Our synthetic strategy towards fumimycin involved the following steps: Dakin oxidation of an aldehyde functionality, conversion of an oxime through radical fragmentation to form an N-diphenylphosphoryl group, construction of an α-trisubstituted amine by 1,2-addition to a ketimine, a Claisen rearrangement with subsequent transition-metal-catalyzed olefin isomerization to install a propenyl chain and final amidation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Productos Biológicos
/
Amidohidrolasas
/
Antibacterianos
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania