Metabolic aspects of prion diseases: an overview.
Curr Drug Targets
; 11(10): 1207-17, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20840065
Prion diseases are fatal neurodegenerative disorders that affect humans and other mammals. The hallmark of these diseases is the conformational change of the cellular prion protein (PrP(C)) to the misfolded protein capable of propagation and associated with neurodegenration, named prion (PrP(Sc)). In a strict sense, prion diseases are a consequence of aberrations in the metabolism of the cellular prion protein (PrP(C)). This brief review addresses current understanding of metabolic disturbances in prion disorders at the cellular, organ and organism level, selectively pointing out some relevant diagnostic and treatment options.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades por Prión
/
Proteínas PrPSc
/
Proteínas PrPC
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Drug Targets
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2010
Tipo del documento:
Article
País de afiliación:
Eslovenia
Pais de publicación:
Emiratos Árabes Unidos