Hepatoprotective effect of an immortal human fetal hepatic cell transplantation on CCL(4)-induced acute liver injury in mice.
Transplant Proc
; 42(7): 2782-5, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20832587
Hepatocyte transplantation has been widely confirmed in the animal model experiments as an effective method for treatment of fulminant hepatic failure. However, the lack of donor organs remains a major problem. One solution is the development of transplantable hepatocytes. Herein we have transplanted intraperitoneally an established immortalized human fetal hepatic cell line (HL-7702) into CCl(4)-treated mice with acute liver injury to determine whether they provided life-saving metabolic support. The results showed lower levels of blood ammonia and higher content of liver albumin (P < .05) after HL-7702 transplantation versus nontransplanted controls at days 3 and 7. Histologic examination showed the transplantation group to be less affected at day 7 with no difference at day 14. In conclusion, an established immortal human fetal hepatic cell line may be a promising cell source providing life-saving metabolic support as a bioartificial liver device for the treatment of acute liver injury.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetracloruro de Carbono
/
Fallo Hepático Agudo
/
Hepatocitos
/
Hígado
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Transplant Proc
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos