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Obsessive-compulsive behavior as a symptom of dementia in progressive supranuclear palsy.
Fukui, T; Lee, E; Hosoda, H; Okita, K.
Afiliación
  • Fukui T; Department of Internal Medicine, Division of Neurology, Showa University Northern Yokohama Hospital, Yokohama, Japan. tfukui@med.showa-u.ac.jp
Dement Geriatr Cogn Disord ; 30(2): 179-88, 2010.
Article en En | MEDLINE | ID: mdl-20798538
AIMS: To describe obsessive-compulsive symptoms (OCS) as under-recognized behavioral and psychological symptoms of dementia of progressive supranuclear palsy (PSP) and to discuss possible mechanisms based on MRI and SPECT findings. METHODS: We studied 74 PSP patients. OCS are defined as persistent and unreasonable, but non-delusional/hallucinatory, ideas and behaviors. Demography, cognition, the widths of middle cerebellar peduncles (MCP) and the inter-caudate distances (ICD), both corrected by the intracranial size (MCP and ICD ratios), and changes on voxel-based SPECT were compared between the subgroups with and without OCS. Finally, the predicative power of various factors to OCS was investigated. RESULTS: We observed OCS in 18 patients (24%). They were obsessed with daily trifles and physical symptoms among other things. OCS was not associated with demography or cognitive levels. OCS-positive patients had significantly smaller MCP and ICD ratios and showed marked uptake decreases in the orbitofrontal cortex, caudate and thalamus. Relative uptake increases in the cerebellum, specifically the tonsils, were milder in OCS-positive than -negative patients. A smaller right MCP, a smaller ICD ratio and lower uptake increases in the right cerebellar were the significant predictors of OCS. CONCLUSIONS: OCS are frequent but under-recognized behavioral and psychological symptoms of dementia in PSP. Dysfunction of the fronto-caudate-thalamus-cerebellum circuit may be involved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Parálisis Supranuclear Progresiva / Cerebelo / Conducta Compulsiva / Conducta Obsesiva Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Dement Geriatr Cogn Disord Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2010 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Parálisis Supranuclear Progresiva / Cerebelo / Conducta Compulsiva / Conducta Obsesiva Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Dement Geriatr Cogn Disord Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2010 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza