[Erythropoietin and neuroprotection]. / Erythropoïétine et neuroprotection.
Arch Pediatr
; 17 Suppl 3: S78-84, 2010 Sep.
Article
en Fr
| MEDLINE
| ID: mdl-20728813
Erythropoietin (Epo) has long been recognised for its role in the control of erythropoiesis and therefore in the treatment of anemia including anemia of prematurity. The erythropoietin receptor (Epo-R) though is expressed in many other organs including the CNS. This review focuses on the role of erythropoietin during the development of the CNS and its potential role as a neuroprotective agent. Epo-R is expressed in many different cellules of the CNS during development including neural progenitor cells, neurons, astrocytes and oligodendrocytes. In the event of hypoxia CNS cells respond with increase of erythropoietin release with subsequent stimulation of neurogenesis through Epo-R on neural progenitor cells. In an Epo-R knock-out model therefore cerebral development is severely impaired. In models of hypoxia-ischemia exogenous Epo has been shown to reduce lesion size and improve structural and functional recovery. Human studies are emerging using Epo as a neuroprotective agent both for the term infant with hypoxia-ischemia as well as for the extremely preterm infant.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Eritropoyetina
/
Enfermedades del Prematuro
Límite:
Humans
/
Newborn
Idioma:
Fr
Revista:
Arch Pediatr
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Francia