Down regulation of lamins A and C by murine interferon beta.

Alldridge, L C; O'Farrell, M K; Dealtry, G B

Alldridge, L C; O'Farrell, M K; Dealtry, G B.

Afiliación

Alldridge LC; Department of Biology, University of Essex, Wivenhoe Park, Colchester, United Kingdom.

Exp Cell Res ; 195(2): 546-50, 1991 Aug.

Article en En | MEDLINE | ID: mdl-2070836

RESUMEN

Treatment of spontaneously differentiated PSMB embryonal carcinoma cells with murine interferon beta results in a transient decrease in the expression of the nuclear lamins A and C. Reduced levels of mRNAs were observed 4 h after the addition of interferon beta, with reductions in the polypeptides and assembled proteins within the nuclear lamina seen after 8 h of treatment. Expression of the 72-kDa (lamin A) and the 62-kDa (lamin C) polypeptides remained down regulated for 8 h, returning to control levels after 16 h of interferon treatment. The specificity of this response is indicated by the inhibitory action of a neutralizing antibody to interferon.

Asunto(s)

Interferón Tipo I/farmacología; Proteínas Nucleares/efectos de los fármacos; Animales; Anticuerpos/inmunología; Western Blotting; Células Madre de Carcinoma Embrionario; Técnica del Anticuerpo Fluorescente; Interferón Tipo I/inmunología; Lamina Tipo A; Laminas; Ratones; Células Madre Neoplásicas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Interferón Tipo I Límite: Animals Idioma: En Revista: Exp Cell Res Año: 1991 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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