[Large cell neuroendocrine carcinoma of the mediastinum].

Nojima, Daisuke; Kiura, Katsuyuki; Hotta, Katsuyuki; Takigawa, Nagio; Tabata, Masahiro; Tanimoto, Mitsune

Nojima, Daisuke; Kiura, Katsuyuki; Hotta, Katsuyuki; Takigawa, Nagio; Tabata, Masahiro; Tanimoto, Mitsune.

Afiliación

Nojima D; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Nihon Kokyuki Gakkai Zasshi ; 48(7): 506-10, 2010 Jul.

Article en Ja | MEDLINE | ID: mdl-20684214

RESUMEN

We describe a rare case of primary mediastinal large cell neuroendocrine carcinoma (LCNEC) with brain metastases. A 65-year-old man presented with a mediastinal abnormal shadow on chest radiography. A computed tomography-guided needle biopsy of the mediastinal tumor revealed malignant cells. After biopsy, dyspnea, leg weakness and a waddling gait rapidly developed. Magnetic resonance imaging of the brain revealed three masses with ring enhancements. His pro-GRP value was 95.5 pg/ml. Since the cerebellar tumor extended to the brain stem, it was removed surgically. The brain tumor demonstrated LCNEC. He received systemic chemotherapy of cisplatin and irinotecan, because his leg weakness and waddling gait had improved markedly after surgery followed by whole brain irradiation.

Asunto(s)

Carcinoma Neuroendocrino/patología; Neoplasias del Mediastino/patología; Anciano; Neoplasias Encefálicas/secundario; Humanos; Masculino

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Neuroendocrino / Neoplasias del Mediastino Límite: Aged / Humans / Male Idioma: Ja Revista: Nihon Kokyuki Gakkai Zasshi Año: 2010 Tipo del documento: Article Pais de publicación: Japón

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