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Target volume delineation for preoperative radiotherapy of rectal cancer: inter-observer variability and potential impact of FDG-PET/CT imaging.
Krengli, Marco; Cannillo, Barbara; Turri, Lucia; Bagnasacco, Paolo; Berretta, Laura; Ferrara, Teresa; Galliano, Mario; Gribaudo, Sergio; Melano, Antonella; Munoz, Fernando; Sciacero, Piera; Tseroni, Vassiliki; Bassi, Maria Chiara; Brambilla, Marco; Inglese, Eugenio.
Afiliación
  • Krengli M; Radiotherapy, University Hospital Maggiore della Carita, via Solaroli 17, 28100 Novara, Italy. krengli@med.unipmn.it
Technol Cancer Res Treat ; 9(4): 393-8, 2010 Aug.
Article en En | MEDLINE | ID: mdl-20626204
To analyze the inter-observer variability and the potential impact of (18)F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coefficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc +/- 20.4 cc in case A and 119 cc +/- 35.7 cc in case B. Mean CTV was 723 cc +/- 147.5 cc in case A and 739 cc +/- 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Planificación de la Radioterapia Asistida por Computador / Tomografía Computarizada por Rayos X / Fluorodesoxiglucosa F18 / Tomografía de Emisión de Positrones Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Technol Cancer Res Treat Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Planificación de la Radioterapia Asistida por Computador / Tomografía Computarizada por Rayos X / Fluorodesoxiglucosa F18 / Tomografía de Emisión de Positrones Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Technol Cancer Res Treat Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos